Budada Soosaarka Catharanthus Roseus
Budada laga soo saaro Catharanthus roseuswaa nooc budo ah oo laga soo saaray geedka Catharanthus roseus, oo sidoo kale loo yaqaan Madagascar periwinkle ama rosy periwinkle. Geedkani waxaa loo yaqaanaa sifooyinkiisa daawada wuxuuna ka kooban yahay iskudhisyo kala duwan oo noole firfircoon, oo ay ku jiraan alkaloids sida vinblastine iyo vincristine, kuwaas oo lagu bartay sifooyinka ka hortagga kansarka ee suurtagalka ah.
Budada laga soo saaro waxaa caadi ahaan laga helaa iyada oo laga soo saaro isku-dhafka noolaha firfircoon ee laga helo walxaha dhirta ka dibna loo farsameeyo qaab budo ah si loogu isticmaalo adeegyo kala duwan. Waxaa loo isticmaali karaa daawada dhaqanka, daawooyinka, ama goobaha cilmi-baarista sababtoo ah sifooyinka daawada ee suurtagalka ah.
Catharanthus roseus waxaa loo yaqaanaa inay tahay geed daawo oo caan ah sababtoo ah waxay ka kooban tahay laba alkaloids oo ka hortaga burooyinka terpenoid indole (TIAs), vinblastine iyo vincristine. Daawada dhaqameed ee Shiinaha, soosaarka geedka waxaa loo isticmaali jiray in lagu daaweeyo cudurrada sida duumada, sonkorowga, iyo lymphoma-ka Hodgkin. Sannadihii 1950-meeyadii, alkaloids-ka vinca waxaa laga soocay Catharanthus roseus iyadoo la baarayo daawooyinka ka hortagga sonkorowga.
Catharanthus roseus, oo badanaa loo yaqaan "Catharanthus roseus"Indho dhalaalaya, Cape periwinkle, geedka qabriga, Madagascar periwinkle, gabdh gabowday, casaan periwinkle, orubax periwinkle ah, waa nooc ubaxeed oo waara oo ka tirsan qoyska Apocynaceae. Waa geed asal ahaan ka soo jeeda Madagascar laakiin waxaa lagu beeraa meel kale oo ah geed qurxin iyo daawo ah, haddana waxay leedahay qayb ka mid ah pantropical. Waa isha daawooyinka vincristine iyo vinblastine, oo loo isticmaalo daaweynta kansarka. Waxaa hore loogu daray hidde-sidaha Vinca sidaUbax Vinca. Waxay leedahay magacyo luqadeed oo badan oo ay ka mid yihiin arivotaombelona ama rivotambelona, tonga, tongatse ama trongatse, tsimatiririnina, iyo vonenina.
| Waxyaabaha ugu Muhiimsan ee Firfircoon ee Shiinaha | Magaca Ingiriisiga | Lambarka CAS. | Miisaanka Molekulerka | Qaacidda Molekuleerigga |
| 长春胺 | Vincamine | 1617-90-9 | 354.44 | C21H26N2O3 |
| 脱水长春碱 | Anhydrovinblastine | 38390-45-3 | 792.96 | C46H56N4O8 |
| 異長春花苷內酰胺 | Strictosamide | 23141-25-5 | 498.53 | C26H30N2O8 |
| 四氢鸭脚木碱 | Tetrahydroalstoneine | 6474-90-4 | 352.43 | C21H24N2O3 |
| 酒石酸长春瑞滨 | Vinorelbine Tartrate | 125317-39-7 | 1079.12 | C45H54N4O8.2(C4H6O6);C |
| 长春瑞滨 | Vinorelbin | 71486-22-1 | 778.93 | C45H54N4O8 |
| 长春新碱 | Vincristine | 57-22-7 | 824.96 | C46H56N4O10 |
| 硫酸长春新碱 | Vincristine sulfate | 2068-78-2 | 923.04 | C46H58N4O14S |
| 硫酸长春质碱 | Catharanthine Sulfate | 70674-90-7 | 434.51 | C21H26N2O6S |
| 酒石酸长春质碱 | Catharanthine hemitartrate | 4168-17-6 | 486.51 | C21H24N2O2.C4H6O6 |
| 长春花碱 | Vinblastine | 865-21-4 | 810.99 | C46H58N4O9 |
| 长春质碱 | Catharanthin | 2468-21-5 | 336.43 | C21H24N2O2 |
| 文朵灵 | Vindoline | 2182-14-1 | 456.53 | C25H32N2O6 |
| 硫酸长春碱 | Vinblastine Sulfate | 143-67-9 | 909.05 | C46H60N4O13S |
| β-谷甾醇 | β-Sitosterol | 83-46-5 | 414.71 | C29H50O |
| 菜油甾醇 | Campesterol | 474-62-4 | 400.68 | C28H48O |
| 齐墩果酸 | Aashitada oleanolic | 508-02-1 | 456.7 | C30H48O3 |
| QIIMEYNTA ALAABTA | ||
| Magaca Badeecada: | Vinca rosea laga soo saaray | |
| Magaca Dhirta: | Catharanthus roseus (L.) | |
| Qayb ka mid ah geedka | Ubax | |
| Dalka Asalka: | Shiinaha | |
| ALAABADA FALANQAYNTA | QEEXIDDA | HABKA IMTIXAANKA |
| Muuqaalka | Budada fiican | Organoleptic |
| Midab | Budada buniga ah ee khafiifka ah | Muuqaal |
| Ur iyo Dhadhan | Sifo | Organoleptic |
| Aqoonsiga | La mid ah muunadda RS | HPTLC |
| Saamiga Soosaarka | 4:1~20:1 | |
| Falanqaynta Shaandhada | 100% ilaa 80 mesh | USP39 <786> |
| Lumis marka la qalajiyo | ≤ 5.0% | Yuuro.Ph.9.0 [2.5.12] |
| Dambas Dhammaad ah | ≤ 5.0% | Yuuro.Ph.9.0 [2.4.16] |
| Rasaasta (Pb) | ≤ 3.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Arsenic (As) | ≤ 1.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Cadmium (Cd) | ≤ 1.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Meerkuriga (Hg) | ≤ 0.1 mg/kg -Reg.EC629/2008 | Eur.Ph.9.0<2.2.58>ICP-MS |
| Bir culus | ≤ 10.0 mg/kg | Yuuro.Ph.9.0 <2.4.8> |
| Haraaga dareeraha | U hoggaansan Eur.ph. 9.0 <5,4 > iyo Tilmaamaha Yurub ee EC 2009/32 | Yuuro.Ph.9.0 <2.4.24> |
| Haraaga Cayayaanka | Xeerarka u Hoggaansan (EC) No.396/2005 oo ay ku jiraan lifaaqyada iyo cusbooneysiinta is daba joogga ah Diiwaanka 2008/839/CE | Karoomatography Gaaska |
| Bakteeriyada hawada ku shaqeysa (TAMC) | ≤10000 cfu/g | USP39 <61> |
| Khamiirka/Caaryada (TAMC) | ≤1000 cfu/g | USP39 <61> |
| Escherichia coli: | Maqna 1g | USP39 <62> |
| bakteeriyada Salmonella: | Ma jiro 25g | USP39 <62> |
| Staphylococcus aureus: | Maqna 1g | |
| Listeria Monocytogenens | Ma jiro 25g | |
| Aflatoxins B1 | ≤ 5 ppb -Reg.EC 1881/2006 | USP39 <62> |
| Aflatoxins ∑ B1, B2, G1, G2 | ≤ 10 ppb -Reg.EC 1881/2006 | USP39 <62> |
Budada laga soosaaray Catharanthus roseus, ama soosaarka rosea Vinca, oo laga soo saaray geedka periwinkle ee Madagascar, wuxuu leeyahay dhowr astaamood oo la taaban karo:
Isku-dhafka Bayoolojiga:Budada laga soosaaray waxay ka kooban tahay iskudhisyo firfircoon sida vinblastine iyo vincristine, kuwaas oo loo yaqaan sifooyinkooda daawada ee suurtagalka ah, gaar ahaan daaweynta kansarka.
Sifooyinka Daawada:Budada laga soosaaray waxaa lagu qiimeeyaa faa'iidooyinka caafimaad ee suurtagalka ah, oo ay ku jiraan sifooyinka ka hortagga kansarka, ka hortagga sonkorowga, iyo ka hortagga dhiigkarka, iyo kuwo kale.
Ilaha Dabiiciga ah:Waxaa laga soo qaatay geedka Catharanthus roseus, oo loo yaqaan dabiiciga iyo isticmaalka daawada dhaqameed.
Codsiyada Daawada:Budada laga soosaaray waxay ku habboon tahay in loo isticmaalo qaacidooyinka daawada iyo cilmi-baarista sababtoo ah dabeecadeeda bayoolaji iyo codsiyada daaweynta ee suurtagalka ah.
Tayada iyo Nadiifnimada:Badeecada waxaa loo soo saaraa heerar tayo sare leh, iyadoo la hubinayo daahirnimada, awoodda, iyo joogteynta waxyaabaha ku jira isku-dhafka firfircoon ee bayoolaji.
Xiisaha Cilmi-baarista:Waa mid xiiso u leh cilmi-baarayaasha iyo xirfadlayaasha daryeelka caafimaadka sababtoo ah awooddeeda ay ku horumarin karto alaabada cusub ee dawooyinka iyo daaweynta.
Waa kuwan faa'iidooyinka caafimaad ee budada Catharanthus roseus Extract ee jumlado kooban:
1. Astaamaha suurtagalka ah ee ka hortagga kansarka oo loo aaneynayo joogitaanka alkaloids-ka vinblastine iyo vincristine.
2. Cilmi-baaristu waxay soo jeedinaysaa saameyn ka hortagta sonkorowga, taasoo laga yaabo inay gacan ka geysato maaraynta sonkorta dhiigga.
3. Isticmaalka suurtagalka ah ee maaraynta dhiigkarka sababtoo ah sifooyinka hypotensive-ka ee la soo sheegay.
4. Waxaa la baaray awooddeeda jeermiska dila iyo fayraska ee taageeridda caafimaadka difaaca jirka.
5. Cilmi-baaris ku samee xiisaha sifooyinka difaaca neerfaha si loo helo taageerada caafimaadka garashada.
6. Adeegsiga suurtagalka ah ee qaababka daryeelka maqaarka sababtoo ah sifooyinka antioxidant-ka ee la soo sheegay.
7. Waxaa lagu bartay saameynteeda ka hortagga bararka, taasoo saameyn ku yeelan karta xaalado caafimaad oo kala duwan.
8. Waxaa la baaray awoodda ay u leedahay inay taageerto fayoobaanta guud iyo firfircoonida.
1. Qaababka ka hortagga kansarka iyo cilmi-baarista ay sabab u tahay joogitaanka vinblastine iyo vincristine alkaloids.
2. Horumarinta daawooyinka ka hortagga sonkorowga iyo kaabisyada.
3. Isticmaalka suurtagalka ah ee maaraynta dhiigkarka iyo daawooyinka la xiriira.
4. Cilmi-baaris ku saabsan wakiilada cusub ee daaweynta xaaladaha caafimaad ee kala duwan.
5. Waxyaabaha ku jira daawada dhaqameedka iyo daawooyinka dhirta.
6. Sahaminta sifooyinka ay u leedahay daryeelka maqaarka iyo qaababka qurxinta.
7. Baaritaan ku saabsan kartidiisa daaweynta caabuqyada bakteeriyada.
8. Horumarinta kaabayaasha cuntada ee loogu talagalay taageerada caafimaadka iyo fayoobaanta guud.
9. Cilmi-baaris ku saabsan faa'iidooyinkeeda caafimaadka ee difaaca neerfaha iyo garashada.
10. Adeegsiga suurtagalka ah ee daawada xoolaha iyo alaabada caafimaadka xoolaha.
Codsiyadani waxay muujinayaan isticmaalka kala duwan ee suurtagalka ah ee Catharanthus roseus Extract Powder ee dawooyinka, daryeelka caafimaadka, fayoobaanta, iyo qaybaha cilmi-baarista.
Budada soosaarka Catharanthus roseus, sida badeecooyin badan oo dabiici ah, waxay yeelan kartaa waxyeellooyin suurtagal ah, gaar ahaan marka loo isticmaalo qaabab xooggan. Qaar ka mid ah waxyeellooyinka suurtagalka ah waxaa ka mid noqon kara:
Dhibaatooyinka Xiidmaha Caloosha:Sida lallabbo, matag, ama shuban dadka qaar.
Dhiig-karka:Sababtoo ah sifooyinka hypotensive-ka ee la soo sheegay, isticmaalka xad-dhaafka ah wuxuu keeni karaa dhiigkar hooseeya.
Saamaynta neerfaha:Qiyaaso badan ayaa keeni kara calaamadaha neerfaha sida wareer ama jahawareer.
Falcelinta Xasaasiyadda:Dadka qaar waxay la kulmi karaan falcelin xasaasiyadeed, gaar ahaan haddii ay yaqaanaan xasaasiyadda dhirta.
Isdhexgalka Daawada:Waxay la falgeli kartaa daawooyin gaar ah, sidaa darteed taxaddar ayaa lagula talinayaa, gaar ahaan shakhsiyaadka qaata daawooyinka kale.
Waa muhiim inaad la tashato xirfadle daryeel caafimaad ka hor intaadan isticmaalin budada Catharanthus roseus Extract, gaar ahaan haddii aad qabto xaalado caafimaad oo hoose ama aad qaadanayso daawooyin. Tani waxay kaa caawin doontaa inaad hubiso in si ammaan ah loo isticmaalo.
Baakadeynta iyo Adeegga
Baakad
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Degdegga ah
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Faahfaahinta Wax Soo Saarka (Jaantuska Socodka)
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