Kaalshiyamka Methyltetrahydrofolate saafiga ah (5MTHF-Ca)
Kaalshiyamka Methyltetrahydrofolate ee saafiga ah (5-MTHF-Ca) waa nooc ka mid ah folate kaas oo si aad ah loo heli karo oo si fudud jidhku uga faa'iidaysan karo.Waa cusbada calcium ee methyltetrahydrofolate, taas oo ah qaabka firfircoon ee folate ee jirka.Folate waa fitamiin B lagama maarmaan ah oo door muhiim ah ka ciyaara hababka kala duwan ee unugyada, oo ay ku jiraan isku-darka DNA-da, wax-soo-saarka unugyada dhiigga cas, iyo shaqada habdhiska dareenka.
MTHF-Ca waxaa badanaa loo isticmaalaa kabitaan cunto ah si loo taageero heerarka folate-ka ee shakhsiyaadka laga yaabo inay ku adkaato dheef-shiid kiimikaadka ama nuugista foomka synthetic ee folic acid ee laga helo cuntooyinka la xoojiyay iyo kaabayaasha.Waxay si gaar ah faa'iido u leedahay shakhsiyaadka leh kala duwanaansho hidde-siyeedyo gaar ah oo wax u dhimi kara dheef-shiid kiimikaadka folate.
Kabista MTHF-Ca waxay gacan ka geysan kartaa taageeridda guud ahaan caafimaadka iyo fayoobaanta, gaar ahaan meelaha ay ka midka yihiin caafimaadka wadnaha, horumarinta tuubada neerfaha xilliga uurka, shaqada garashada, iyo habaynta niyadda.Waxaa muhiim ah in la ogaado in MTHF-Ca loo isticmaalo hagida xirfadlaha daryeelka caafimaadka, gaar ahaan shakhsiyaadka leh xaalado caafimaad oo gaar ah ama kuwa qaata daawooyinka qaarkood.
| Magaca alaabta： | L-5-Methyltetrahydrofolate calcium |
| La mid ah： | 6S-5-Methyltetrahydrofolate calcium;Kaalshiyam L-5-Methyltetrahydrofolate;Levomefolate calcium |
| Qaanuunka molecular: | C20H23CaN7O6 |
| Miisaanka Molecular: | 497.52 |
| CAS Maya: | 151533-22-1 |
| Nuxurka: | ≥ 95.00% ee HPLC |
| Muuqashada: | Caddaan ilaa iftiin jaale ah budo crystalline |
| Dalka asal ahaan: | Shiinaha |
| Xidhmada: | 20kg/durbaan |
| Nolosha shelf: | 24 bilood |
| Kaydinta: | Ku hay meel qabow&engegan. |
| Walxaha | Tilmaamaha | Natiijooyinka |
| Muuqashada | Caddaan ama budo cad | Xaqiiji |
| Aqoonsiga | Wanagsan | Xaqiiji |
| Calcium | 7.0% -8.5% | 8.4% |
| D-5-Methylfolate | ≤1.0 | Lama ogaan |
| Hadhaaga dabka | ≤0.5% | 0.01% |
| Biyo | ≤17.0% | 13.5% |
| Assay (HPLC) | 95.0% -102.0% | 99.5% |
| Dambas | ≤0.1% | 0.05% |
| Birta culus | ≤20 ppm | Xaqiiji |
| Wadarta tirada saxanada | ≤1000cfu/g | U qalma |
| Khamiir & caaryada | ≤100cfu/g | U qalma |
| E.coil | xun | xun |
| Salmonella | xun | xun |
Helitaanka noole sare:MTHF-Ca waa nooc folate ah oo aad loo heli karo, taasoo la macno ah in si fudud loo nuugi karo oo uu jidhku uga faa'iidaysan karo.Tani waa muhiim sababtoo ah shakhsiyaadka qaarkood waxaa laga yaabaa inay ku adkaato inay u beddelaan folic acid-ka synthetic qaabkeeda firfircoon.
Qaabka firfircoon ee folate:MTHF-Ca waa qaabka firfircoon ee folate, oo loo yaqaan methyltetrahydrofolate.Foomkan waxa si sahal ah u isticmaala jidhku umana baahna habab beddelaad dheeraad ah.
Calcium cusbo:MTHF-Ca waa milix kalsiyum ah, taas oo macnaheedu yahay inay ku xidhan tahay calcium.Tani waxay bixisaa faa'iidada dheeraadka ah ee kaalshiyamka kaalshiyamka oo ay la socoto taageerada folate.Kaalshiyamku waxa uu lagama maarmaan u yahay caafimaadka lafaha, shaqada murqaha, gudbinta neerfaha, iyo hawlaha kale ee jidhka.
Ku habboon shakhsiyaadka leh kala duwanaanshaha hidde-sidaha gaarka ah:MTHF-Ca waxay si gaar ah faa'iido ugu leedahay shakhsiyaadka leh kala duwanaansho hidde-siyeedyo gaar ah oo wax u dhimi kara dheef-shiid kiimikaadka folate.Kala duwanaanshahan hidde-sideyaasha ahi waxay saamayn karaan awoodda jidhku u leeyahay in uu folic acid u beddelo qaabkeeda firfircoon, taas oo ka dhigaysa kaabista folate firfircoon ee lagama maarmaanka ah.
Waxay taageertaa dhinacyada kala duwan ee caafimaadka:Kaabista MTHF-Ca waxay taageeri kartaa guud ahaan caafimaadka iyo fayoobida.Waxay si gaar ah faa'iido u leedahay caafimaadka wadnaha iyo xididdada dhiigga, horumarinta tuubada neerfaha xilliga uurka, shaqada garashada, iyo xakamaynta niyadda.
Methyltetrahydrofolate Calcium (MTHF-Ca) waxay bixisaa faa'iidooyin caafimaad oo dhowr ah:
Taageerada dheef-shiid kiimikaadka folate:MTHF-Ca waa folate aad loo heli karo oo firfircoon.Waxay gacan ka geysataa taageeridda dheef-shiid kiimikaadka folate-ka ee jirka, kaas oo muhiim u ah isku-dhafka DNA-ga, wax-soo-saarka unugyada dhiigga cas, iyo guud ahaan shaqada gacanta.
Caafimaadka Wadnaha:Heerarka folate ku filan ayaa lagama maarmaan u ah caafimaadka wadnaha iyo xididdada dhiigga.Kaabista MTHF-Ca waxay kaa caawin kartaa dhimista heerarka homocysteine , amino acid, marka kor loo qaado, waxay la xiriirtaa khatarta sii kordheysa ee cudurada wadnaha.
Taageerada uurka:MTHF-Ca waa muhiim xilliga uurka, maadaama ay ka caawiso ka hortagga cilladaha tuubada neerfaha ee horumarinta uurjiifka.Waxaa lagula talinayaa haweenka ku jira da'da dhalmada si loo hubiyo inay leeyihiin heerar folate ku filan, gaar ahaan inta lagu jiro marxaladaha hore ee uurka.
Nidaaminta niyadda:Folate wuxuu door muhiim ah ka ciyaaraa isku dhafka neurotransmitter.Heerarka folate ee ku filan ayaa taageera soo saarista serotonin, dopamine, iyo norepinephrine, kuwaas oo muhiim u ah xakamaynta niyadda.Kaabista MTHF-Ca waxay faa'iido u yeelan kartaa shakhsiyaadka qaba xanuunka niyadda, sida niyad-jabka.
Shaqada garashada:Folate waxay lagama maarmaan u tahay shaqada garashada iyo caafimaadka maskaxda.MTHF-Ca kabitaanku waxa laga yaabaa inay taageerto xusuusta, fiirsashada, iyo guud ahaan waxqabadka garashada, gaar ahaan dadka waaweyn.
Taageerada nafaqada:Kaabista MTHF-Ca waxay faa'iido u yeelan kartaa shakhsiyaadka leh kala duwanaanshiyaha hidda-socodka ee saameeya dheef-shiid kiimikaad.Shakhsiyaadkan waxaa laga yaabaa inay ku adkaato inay u beddelaan folic acid-ka synthetic qaabkeeda firfircoon.MTHF-Ca waxay si toos ah u bixisaa qaabka firfircoon ee folate, iyada oo ka gudubta wax kasta oo ku saabsan beddelidda.
Nafaqooyinka iyo kaabista cuntada:MTHF-Ca waxaa caadi ahaan loo isticmaalaa sida qayb muhiim ah oo ka mid ah kaabayaasha nafaqeynta iyo nafaqeynta.Waxay bixisaa nooc folate ah oo aad loo heli karo, oo bixisa faa'iidooyin caafimaad oo badan, sidaan hore u soo sheegnay.
Xoojinta cuntada iyo cabitaanka:MTHF-Ca waxaa lagu dari karaa cuntada iyo alaabta cabitaanka si loogu xoojiyo folate.Tani waxay si gaar ah muhiim ugu tahay alaabada u adeegta dadka leh cilladaha folate-ka ama baahida folate-ka oo korodhay, sida haweenka uurka leh ama shakhsiyaadka leh xaalado caafimaad qaarkood.
Qaababka dawooyinka:MTHF-Ca waxaa loo isticmaali karaa habaynta dawooyinka sida walax firfircoon.Waxa laga yaabaa in loo isticmaalo dawooyinka lagu beegsanayo xaalado gaar ah oo la xidhiidha yaraanta folate-ka ama dheef-shiid kiimikaadka folate-ka daciifka ah, sida dhiig-yaraan ama xanuunnada hidde-sideyaasha qaarkood.
Daryeelka shakhsi ahaaneed iyo waxyaabaha la isku qurxiyo:MTHF-Ca mararka qaarkood waxaa lagu daraa alaabta daryeelka shakhsi ahaaneed iyo waxyaalaha la isku qurxiyo sababtoo ah faa'iidooyinka ay u leedahay caafimaadka maqaarka.Folate wuxuu ku lug leeyahay hababka kala duwan ee unugyada maqaarka waxaana laga yaabaa inay wax ka tarto caafimaadkiisa iyo muuqaalkiisa guud.
Quudinta xoolaha:MTHF-Ca sidoo kale waxaa lagu dari karaa quudinta xoolaha si loogu kabo xayawaanka folate.Tani waxay si gaar ah u khusaysaa xoolaha iyo warshadaha digaaga, halkaas oo hubinta nafaqo ku filan koritaanka iyo caafimaadka ugu fiican ay lagama maarmaan tahay.
Goobahan codsiyadu waxay muujinayaan wax-ku-oolnimada MTHF-Ca iyo isticmaalka suurtogalka ah ee warshado kala duwan si wax looga qabto welwelka caafimaad ee la xiriira folate iyo baahiyaha nafaqeynta.Si kastaba ha ahaatee, waxaa muhiim ah in la raaco tilmaamaha qiyaasta saxda ah oo lala tashado xirfadlayaasha marka lagu daro MTHF-Ca badeecad kasta ama qaabaynta.
Helitaanka alaabta ceeriin:Nidaamku wuxuu ku bilaabmayaa soo saarista alaabta ceeriin oo tayo sare leh.Qalabka ceeriin ee aasaasiga ah ee looga baahan yahay soo saarista MTHF-Ca waa folic acid iyo cusbada calcium.
U beddelashada folic acid una beddelo 5,10-Methylenetetrahydrofolate (5,10-MTHF):Folic acid waxa loo beddelaa 5,10-MTHF iyada oo loo marayo habka dhimista.Talaabadani waxay caadi ahaan ku lug leedahay isticmaalka walxaha yareeya sida sodium borohydride ama kicinta kale ee ku haboon.
U beddelashada 5,10-MTHF ee MTHF-Ca:5,10-MTHF waxaa lagu sii falceliyaa cusbada calcium ku habboon, sida calcium hydroxide ama calcium carbonate, si loo sameeyo Methyltetrahydrofolate Calcium (MTHF-Ca).Habkani wuxuu ku lug leeyahay isku-darka fal-celiyeyaasha oo u oggolaanaya inay ka fal-celiyaan xaaladaha la xakameeyey, oo ay ku jiraan heerkulka, pH, iyo wakhtiga falcelinta.
Sifaynta iyo sifaynta:Falcelinta ka dib, xalka MTHF-Ca wuxuu maraa hababka nadiifinta sida sifaynta, centrifugation, ama farsamooyinka kale ee kala soocida si meesha looga saaro wasakhda iyo alaabada laga yaabo inay abuurmeen intii lagu jiray falcelinta.
Qalajinta iyo adkaynta:Xalka MTHF-Ca ee la safeeyey ayaa markaa si dheeraad ah loo farsameeyaa si meesha looga saaro qoyaanka xad-dhaafka ah iyo xoojinta alaabta ugu dambeysa.Tan waxaa lagu gaari karaa farsamooyin sida qalajinta buufinta ama qalajinta qaboojinta, iyadoo ku xiran nooca badeecada la rabo.
Xakamaynta tayada iyo tijaabinta:Alaabada ugu dambeysa ee MTHF-Ca waxaa lagu soo rogay tallaabooyin adag oo lagu xakameynayo tayada si loo hubiyo nadiifnimadeeda, xasilloonida, iyo u hoggaansanaanta heerarka tayada cayiman.Tan waxaa ku jiri kara tijaabinta wasakhda, awoodda, iyo cabbirrada kale ee khuseeya.
Baakadaha iyo kaydinta:MTHF-Ca waxay ku jirtaa weelal ku habboon, iyadoo hubinaysa calaamadaynta habboon iyo xaaladaha kaydinta si loo ilaaliyo daacadnimadeeda iyo xasilloonida.Badanaa waxaa lagu kaydiyaa meel qalalan oo qabow oo ka fog iftiinka qorraxda tooska ah.
Kaydinta: Ku hay meel qabow, qalalan, oo nadiif ah, Ka ilaali qoyaanka iyo iftiinka tooska ah.
Xidhmada badan: 25kg / durbaan.
Waqtiga Hogaaminta: 7 maalmood kadib dalabkaaga.
Nolosha shelf: 2 sano.
Fiiro gaar ah: Tilmaamaha gaarka ah sidoo kale waa la gaari karaa.
20kg/bac 500kg/pallet
Baakadaha la xoojiyay
Ammaanka saadka
Express
Ka yar 100kg, 3-5 maalmood
Adeegga albaab ilaa albaab si fudud alaabta looga soo qaadan karo
By Badda
In ka badan 300kg, Qiyaastii 30 maalmood
Dekadda ilaa iyo dakadda waxa loo baahan yahay dilaaliinta nadiifinta xirfada leh
By Hawada
100kg-1000kg, 5-7 maalmood
Gegida dayuuradaha ilaa madaarka dallaalka nadiifinta xirfadlayaasha ah ayaa loo baahan yahay
Methyltetrahydrofolate Calcium saafi ah (5-MTHF-Ca)waxaa lagu caddeeyey shahaadada ISO, shahaado HALAL, iyo shahaado KOSHER.
Farqiga u dhexeeya jiilka afraad ee folic acid (5-MTHF) iyo folic acid dhaqameed waxay ku jirtaa qaab-dhismeedkooda kiimikaad iyo bioavailability ee jirka.
Qaab dhismeedka kiimikada:Asiidh-dhaqameedka folic acid waa nooc ka samaysan folate oo u baahan in la maro tallaabooyin beddelaad badan oo jidhka ah ka hor inta aan laga faa'iidaysan.Dhanka kale, folic acid jiilka afraad, oo sidoo kale loo yaqaan 5-MTHF ama Methyltetrahydrofolate, waa qaab firfircoon, noole ah oo folate ah oo aan u baahnayn beddelaad.
Helitaanka noole:Folic acid dhaqameed waxay u baahan tahay in loo beddelo qaabkeeda firfircoon, 5-MTHF, iyada oo loo marayo falcelinta enzymatic ee jirka.Habka beddelka ayaa ku kala duwan shakhsiyaadka waxaana saameyn kara kala duwanaanshaha hidde-raaca ama arrimo kale.Taas bedelkeeda, 5-MTHF waxay ku jirtaa qaabkeeda firfircoon, taas oo ka dhigaysa mid diyaar u ah qaadashada gacanta iyo isticmaalka.
Nuugista iyo ka faa'iidaysiga:Nuugista folic acid-dhaqameedku waxay ku dhacdaa mindhicirka yar, halkaas oo ay u baahan tahay in lagu beddelo qaabka firfircoon ee enzyme dihydrofolate reductase (DHFR).Si kastaba ha ahaatee, habka beddelka ma aha mid wax ku ool u ah shakhsiyaadka qaarkood, taas oo horseedaysa helitaanka bioavailability hoose.5-MTHF, oo ah qaabka firfircoon, ayaa si fudud u nuugi kara oo ka faa'iideysanaya jirka, isaga oo ka gudbaya habka beddelka.Tani waxay ka dhigaysaa qaab la door biday shakhsiyaadka leh kala duwanaansho hidde ama xaalado saameeya dheef-shiid kiimikaadka folate.
Jir-dhiska shaqsiyaad gaar ah:Sababtoo ah kala duwanaanshaha nuugista iyo ka faa'iidaysiga, 5-MTHF waxaa loo arkaa inay ku habboon tahay shakhsiyaadka leh kala duwanaansho hidde-sidaha qaarkood, sida isbeddellada hidda-wadaha MTHFR, taas oo wax u dhimi karta beddelka folic acid qaabkeeda firfircoon.Shakhsiyaadkan, iyadoo la adeegsanayo 5-MTHF si toos ah waxay xaqiijin kartaa heerarka folate ee saxda ah ee jirka waxayna taageertaa hawlaha noolaha ee kala duwan.
Kaabista:Asiidh-dhaqameedka folic acid waxaa caadi ahaan laga helaa kaabayaasha, cuntooyinka la xoojiyay, iyo cuntooyinka warshadaysan, maadaama ay aad u deggan tahay oo ay ka jaban tahay soo saarista.Si kastaba ha ahaatee, waxaa jira helitaanka sii kordhaya ee 5-MTHF supplements kuwaas oo si toos ah u bixiya foomka firfircoon, taas oo faa'iido u yeelan karta shakhsiyaadka ay ku adagtahay beddelka folic acid.
Dhibaatooyinka soo raaca ee jiilka afraad ee folic acid (5-MTHF) guud ahaan waa dhif iyo naadir, laakiin waxaa muhiim ah in laga digtoonaado falcelinta iman karta:
Dareen-celinta xasaasiyadda:Si la mid ah wax kasta oo dheeri ah ama daawooyin ah, dareen-celinta xasaasiyaddu waa suurtogal.Calaamadaha waxaa ka mid noqon kara finan, cuncun, barar, dawakhaad, ama neefsashada oo ku adkaata.Haddii aad isku aragto mid ka mid ah calaamadahan, raadso daryeel caafimaad oo degdeg ah.
Arrimaha dheefshiidka:Shakhsiyaadka qaarkood ayaa laga yaabaa inay la kulmaan raaxo-darrada caloosha, sida lallabbo, dibiro, gaas, ama shuban.Calaamadahani inta badan waa ku meel gaadh wayna dagaan marka jidhku la qabsado kaabista.
Isdhexgalka daawooyinka:5-MTHF waxaa laga yaabaa inay la falgasho daawooyinka qaarkood, oo ay ku jiraan daawooyinka loo isticmaalo daawaynta kansarka, anticonvulsants, methotrexate, iyo antibiyootiga qaarkood.Waa muhiim inaad la hadasho bixiyaha xanaanada caafimaadkaaga haddii aad qaadato wax daawo ah si loo hubiyo inaysan jirin is dhexgal suurtagal ah.
Qiyaasta xad dhaafka ah ama xad dhaafka ah ee heerarka folate:Iyadoo naadir ah, qaadashada xad-dhaafka ah ee folate (oo ay ku jiraan 5-MTHF) waxay u horseedi kartaa heerarka dhiigga ee folate.Tani waxay qarin kartaa calaamadaha yaraanta fitamiin B12 waxayna saameyn kartaa ogaanshaha iyo daaweynta xaaladaha qaarkood.Waa muhiim inaad raacdo qiyaasta lagu taliyey oo aad la tashato xirfadle daryeel caafimaad hagid.
Tixgalino kale:Haweenka uurka leh ama kuwa qorsheynaya inay uur qaadaan waa inay la hadlaan bixiyaha xanaanada caafimaadka ka hor intaysan qaadan qiyaaso badan oo ah 5-MTHF, maadaama qaadashada folate-ka xad-dhaafka ah ay qarin karto calaamadaha yaraanta fitamiin B12, taas oo muhiim u ah horumarinta tuubada neerfaha ee uurjiifka.
Sida kaabis kasta oo cunto ah ama daawo, waa lagama maarmaan in lagala hadlo isticmaalka jiilka afraad ee folic acid (5-MTHF) bixiye daryeel caafimaad, gaar ahaan haddii aad leedahay wax xaalado caafimaad oo hoose ah ama aad qaadato daawooyin kale.Waxay ku siin karaan talo shakhsi ahaaneed oo ku salaysan baahiyahaaga gaarka ah waxayna kaa caawin karaan la socodka wixii waxyeelo ah ee iman kara.
Folic acid jiilka afraad, oo sidoo kale loo yaqaan 5-methyltetrahydrofolate (5-MTHF), waa qaab bayooloji ahaan firfircoon oo folate ah kaas oo si fudud u nuugo oo uu isticmaalo jidhku marka la barbar dhigo kabitaannada folic acid dhaqameed.Waa kuwan qaar ka mid ah daraasado cilmiyeed oo taageeraya waxtarkeeda:
Helitaanka noole ee kordhay:5-MTHF ayaa la muujiyay in ay leedahay bioavailability ka weyn folic acid.Daraasad lagu daabacay Joornaalka Maraykanka ee Nafaqada Caafimaadka marka la barbar dhigo bioavailability ee folic acid iyo 5-MTHF ee haweenka caafimaadka qaba.Waxay ogaatay in 5-MTHF si dhakhso ah loo nuugo waxayna keentay heerarka folate-ka sare ee unugyada dhiigga cas.
Heerka folate oo la hagaajiyay:Daraasado dhowr ah ayaa muujiyay in kaabista 5-MTHF ay si wax ku ool ah u kordhin karto heerarka folate-ka dhiigga.Tijaabo la xakameynayo oo la kala soocay oo lagu daabacay Joornaalka Nafaqada, cilmi-baarayaashu waxay barbar dhigeen saameynta 5-MTHF iyo folic acid supplement ee xaaladda folate ee haweenka caafimaadka qaba.Waxay ogaadeen in 5-MTHF ay aad uga waxtar badan tahay kordhinta heerarka folate ee unugyada dhiigga cas marka loo eego folic acid.
Dheef-shiid kiimikaad ee folic acid:5-MTHF ayaa la muujiyay in ay dhaafto tillaabooyinka enzymatic ee looga baahan yahay firfircoonida folic acid oo ay si toos ah uga qayb qaadato dheef-shiid kiimikaadka folic acid-ka gacanta.Daraasad lagu daabacay Joornaalka Nafaqada iyo Dheef-shiid kiimikaadka ayaa muujisay in dheellitirka 5-MTHF uu hagaajiyay dheef-shiid kiimikaadka folate intracellular ee shakhsiyaadka leh kala duwanaanta hidde-socodka ee enzymes ee ku lug leh firfircoonida folic acid.
Heerarka homocysteine ee hoos u dhaca:Heerarka sare ee homocysteine, oo ah amino acid ku jira dhiigga, ayaa lala xiriiriyaa khatarta sii kordheysa ee cudurada wadnaha.Daraasaduhu waxay muujiyeen in dheellitirka 5-MTHF ay si wax ku ool ah u yareeyn karto heerarka homocysteine .Falanqaynta maadada ee lagu daabacay Joornaalka Kulliyadaha Nafaqada ee Maraykanka ayaa falanqeeyay 29 tijaabo oo la kala soocay oo la soo gabagabeeyay in 5-MTHF kabitaanku uu ka waxtar badan yahay folic acid si loo yareeyo heerarka homocysteine .
Waxaa muhiim ah in la ogaado in jawaabaha shakhsi ahaaneed ee kaabista ay kala duwanaan karaan, iyo waxtarka 5-MTHF waxay ku xirnaan kartaa arrimo ay ka mid yihiin kala duwanaanshaha hidde-socodka ee enzymes dheef-shiid kiimikaad iyo guud ahaan qaadashada cuntada.Had iyo jeer waxa lagu taliyaa in aad kala tashato bixiye daryeel caafimaad si aad u hesho tallo gaar ah oo ku saabsan kabidda iyo in lagala hadlo wixii walaac caafimaad oo gaar ah ama xaalado.
