Lycorine Hydrochloride
Lycorine hydrochloride waa budo cad ama caddaan ah oo ka soo jeeda lycorine alkaloid, taas oo laga helo dhirta Lycoris radiata (L'Her.), waxayna ka tirsan tahay qoyska Amaryllidaceae. Lycorine hydrochloride waxay leedahay saameyno kala duwan oo dawooyin ah, oo ay ku jiraan anti-buro, anti-kansarka, anti-HCV, anti-bararka, ka hortagga bakteeriyada, anti-virus, anti-angiogenesis, iyo guryaha ka hortagga duumada. Waxay ku milmi kartaa biyaha, DMSO, iyo ethanol. Qaab dhismeedka kiimikada waxaa lagu gartaa qaab-dhismeedka steroidal adag oo leh dhadhan qadhaadh oo leh kooxo badan oo shaqeynaya, oo ay ku jiraan hydroxyl iyo kooxaha amino, oo gacan ka geysanaya dhaqdhaqaaqyadeeda noolaha.
| Magaca alaabta | Lycorine hydrochloride CAS: 2188-68-3 | ||
| Isha dhirta | Lycoris | ||
| Xaaladda kaydinta | Ku kaydi shaabad heerkulka qolka | Taariikhda warbixinta | 2024.08.24 |
| Shayga | Heerka | Natiijada |
| daahirnimo(HPLC) | Lycorine hydrochloride≥98% | 99.7% |
| Muuqashada | Budada cad-cad | waafaqsan |
| Dabeecad jireedics | ||
| Cabbirka-qayb | NLT100% 80Mesh | waafaqsan |
| Luminta qalajinta | ≤1.0% | 1.8% |
| Culus biraha | ||
| Wadarta biraha | ≤10.0pm | waafaqsan |
| Hogaamin | ≤2.0pm | waafaqsan |
| Meerkuri | ≤1.0pm | waafaqsan |
| Cadmium | ≤0.5pm | waafaqsan |
| Microorganism | ||
| Tirada guud ee bakteeriyada | ≤1000cfu/g | waafaqsan |
| khamiir | ≤100cfu/g | waafaqsan |
| Escherichia coli | Kuma jiraan | Lama ogaan |
| Salmonella | Kuma jiraan | Lama ogaan |
| Staphylococcus | Kuma jiraan | Lama ogaan |
| Gabagabadii | U qalma | |
Astaamaha:
(1) Nadiifin Sare:Alaabtayadu si taxadar leh ayaa loo habeeyey si loo xaqiijiyo nadiifnimada heerka sare, taas oo muhiim u ah waxtarkeeda iyo badbaadada codsiyada kala duwan.
(2) Guryaha Ka-hortagga Kansarka:Waxay muujisay saameyn weyn oo liddi ku ah kansarka noocyada kala duwan ee kansarka, labadaba in vitro iyo in vivo, iyada oo loo marayo habab ay ka mid yihiin kicinta wareegga unugyada, kicinta apoptosis, iyo joojinta angiogenesis.
(3) Tallaabo kala duwan:Lycorine hydrochloride waxaa la rumeysan yahay inay la falgasho bartilmaameedyo badan oo molecular, taasoo bixisa waxtar ballaaran oo ka dhan ah unugyada kansarka.
(4) Sunta Hoose:Waxay muujinaysaa sunta hoose ee unugyada caadiga ah, taas oo ah arrin muhiim u ah isticmaalka suurtagalka ah ee wakiilka daweynta.
(5) Xogta Farmacokinetic:Alaabta ayaa lagu bartay farmashiyaha, taasoo muujinaysa nuugista degdega ah iyo ka takhalusidda degdega ah ee balasmaha, taas oo muhiim u ah qaadashada iyo qorsheynta daawaynta.
(6) Saamaynta Isku-dhafka:Lycorine hydrochloride waxay muujisay saameyn la xoojiyey marka lagu daro daawooyinka kale, taas oo faa'iido u yeelan karta ka gudubka caabbinta daroogada iyo hagaajinta natiijooyinka daaweynta.
(7) Cilmi-baaris lagu taageeray:Badeecada waxaa lagu taageeray cilmi-baaris ballaaran, oo siinaya aasaas adag oo loogu talagalay isticmaalka horumarinta daawooyinka iyo codsiyada bukaan-socodka.
(8) Xaqiijinta tayada:Tallaabooyinka xakamaynta tayada adag ayaa jira inta lagu guda jiro habka wax soo saarka si loo hubiyo joogtaynta iyo isku halaynta alaabta.
(9) Codsiyada kala duwan:Ku habboon isticmaalka cilmi-baarista iyo horumarinta codsiyada dawooyinka, oo ay ku jiraan helitaanka daroogada iyo horumarinta daaweynta kansarka.
(10) U hoggaansanaanta:La soo saaray iyadoo la raacayo heerarka GMP si loo hubiyo badbaadada iyo waxtarka alaabta.
(1) Warshadaha dawooyinka:Lycorine hydrochloride waxaa loo isticmaalaa horumarinta daawooyinka fayraska iyo ka hortagga kansarka.
(2) Warshadaha bayoloji:Waxa loo adeegsadaa cilmi-baadhista iyo horumarinta dawooyinka cusub ee dawooyinka iyo qaab-dhismeedka dawooyinka.
(3) Cilmi-baarista alaabta dabiiciga ah:Lycorine hydrochloride waxaa loo bartay faa'iidooyinka caafimaad ee suurtagalka ah iyo sifooyinka daawooyinka.
(4) Warshadaha Kiimikada:Waxa laga yaabaa in loo isticmaalo sidii dhexdhexaad kiimikaad ah ee isku xidhka xeryahooda kale.
(5) Warshadaha beeraha:Lycorine hydrochloride ayaa lagu baaray awooddeeda sida sunta cayayaanka dabiiciga ah iyo xakameynta koritaanka dhirta.
Habka soo saarista lycorine hydrochloride sida caadiga ah waxaa ku jira tillaabooyinka muhiimka ah ee soo socda si loo hubiyo nadiifnimada dareeraha iyo hagaajinta heerka soo kabashada:
(1) Xulashada alaabta ceeriin iyo ka-hortag:Dooro alaabta ceeriin ee ku habboon ee Amaryllidaceae, sida nalalka Amaryllis, oo dhaq, qalaji oo burburi si aad u hubiso nadiifnimada alaabta ceeriin oo u dhig aasaaska soo saarista xiga.
(2)Kahor daawaynta enzyme isku dhafan:Isticmaal ensaymes isku dhafan (sida cellulase iyo pectinase) si aad u sii diyaarisid alaabta ceeriin ee la jajabiyey si ay u burburiyaan derbiyada unugyada dhirta oo aad u hagaajisid waxtarka soo saarista xiga.
(3)Kala saar dareeraha acid hydrochloric:Ku qas alaabta ceeriin ee hore loo daweeyay iyo milanka acid hydrochloric si loo soo saaro lykorin. Isticmaalka aashitada hydrochloric waxay ka caawisaa inay kordhiso milanka lycorine, taas oo hagaajinaysa waxtarka soo saarista.
(4)Soo saarista Ultrasonic-ku caawisay:Isticmaalka tignoolajiyada soo saarista ee ay caawisay ultrasonic waxay dardar galin kartaa habka kala dirida lycorine ee dareeraha waxayna wanaajisaa hufnaanta soosaarka iyo nadiifnimada.
(5)Soo saarista chloroform:Soo saarista waxaa lagu sameeyaa dareerayaasha organic sida chloroform, iyo lycorine waxaa laga wareejiyaa wajiga aqueous wajiga organic si loo sii nadiifiyo xarunta bartilmaameedka.
(6)Soo kabashada dareeraha:Ka dib habka soo saarista, dareeraha waxaa lagu soo kabsadaa uumi ama uumi si loo yareeyo isticmaalka dareeraha iyo horumarinta dhaqaalaha.
(7)Sifaynta iyo qalajinta:Iyadoo loo marayo tillaabooyinka nadiifinta iyo qalajinta habboon, budada lycorine hydrochloride saafi ah ayaa la helaa.
Inta lagu jiro habka soo saarista oo dhan, xakamaynta xulashada dareeraha, xaaladaha soo saarista (sida qiimaha pH, heerkulka, iyo wakhtiga), iyo tallaabooyinka nadiifinta ee xiga ayaa fure u ah xaqiijinta nadiifinta dareeraha iyo hagaajinta heerka soo kabashada. Isticmaalka qalabka casriga ah ee soo saarista iyo nadiifinta, sida soosaarayaasha ultrasonic iyo hababka chromatography dareeraha waxqabadka sare leh (HPLC), waxay sidoo kale gacan ka geystaan hagaajinta waxtarka soo saarista iyo tayada alaabta.
Kaydinta: Ku hay meel qabow, qalalan, oo nadiif ah, Ka ilaali qoyaanka iyo iftiinka tooska ah.
Xidhmada badan: 25kg / durbaan.
Waqtiga Hogaaminta: 7 maalmood kadib dalabkaaga.
Nolosha shelf: 2 sano.
Fiiro gaar ah: Tilmaamaha gaarka ah sidoo kale waa la gaari karaa.
Express
Ka yar 100kg, 3-5 maalmood
Adeegga albaab ilaa albaab si fudud alaabta looga soo qaadan karo
By Badda
In ka badan 300kg, Qiyaastii 30 maalmood
Dekadda ilaa iyo dakadda waxa loo baahan yahay dilaaliinta nadiifinta xirfada leh
By Hawada
100kg-1000kg, 5-7 maalmood
Gegida dayuuradaha ilaa madaarka dallaalka nadiifinta xirfadlayaasha ah ayaa loo baahan yahay
Bioway Organic waxay heshay USDA iyo EU organic, BRC, ISO, HALAL, KOSHER, iyo shahaadooyin HACCP.
Lycorine waa alkaloid si dabiici ah u dhacda oo laga heli karo dhir badan, gaar ahaan qoyska Amaryllidaceae dhexdeeda. Waa kuwan qaar ka mid ah dhirta loo yaqaan inay ku jiraan lykorin:
Lycoris radiata(sidoo kale loo yaqaan ubaxa caarada cas ama manjushage) waa geedo daawaynta dhaqameed ee Shiinaha oo ka kooban lykorin.
Leucojum aestuum(flake xagaaga), sidoo kale waxaa loo yaqaanaa inay ku jirto lykorin.
Ungernia sewertzowiiwaa geed kale oo ka soo jeeda qoyska Amaryllidaceae oo la sheegay inay ku jirto lykorin.
Hippeastrum hybrid ( ubaxa Easter-ka)iyo dhirta kale ee Amaryllidaceae ee la xidhiidha ayaa ah ilaha loo yaqaan 'lycorine'.
Dhirtan ayaa si weyn ugu baahsan gobolada kulaylaha iyo kulaylaha hoose ee aduunka waxayna leeyihiin taariikh dheer oo laga isticmaalo dawo dhaqameedka. Joogitaanka lycorine ee dhirtaas ayaa ahaa mawduuca cilmi-baarista sababtoo ah sifooyinka farmashiyaha ee suurtogalka ah, oo ay ku jiraan saameynteeda muhiimka ah ee kansarka sida lagu muujiyay daraasado kala duwan.
Lycorine waa alkaloid dabiici ah oo leh saameyn fara badan oo farmaajo ah, oo ay ku jirto isticmaalka suurtagalka ah ee daaweynta kansarka. Iyadoo ay muujisay natiijooyin rajo leh daraasado kala duwan, waxaa jira qaar ka mid ah dhibaatooyinka soo raaca ee la soo sheegay iyo tixgelin la xiriirta isticmaalkeeda:
Sunta Yar: Lycorine iyo milixdeeda hydrochloride guud ahaan waxay muujiyaan sunta hoose, taas oo sifo wanaagsan u ah codsiyada kiliinikada. Waxaa la muujiyay inay saameyn xun ku leedahay unugyada caadiga ah ee bini'aadamka iyo jiirarka caafimaadka qaba, taasoo soo jeedinaysa heer gaar ah oo xulashada unugyada kansarka ee unugyada caadiga ah.
Saamaynta Degdegga ah ee Ku-meel-gaadhka ah: Lallabbo iyo matag ku-meel-gaar ah ayaa la arkay ka dib cirbadeynta lycorine hydrochloride ee jirka hoosteeda ama xididka, oo caadi ahaan hoos u dhacda 2.5 saacadood gudahood iyada oo aan saameyn ku yeelanin biochemical ama badbaadada dhiigga.
Ma jiro Isku-dubarid Dhaqaale Xun: Cilmi-baaristu waxay muujisay in qiyaasaha taxanaha ah ee lycorine aysan saameynaynin isku-dubbaridka dhaqdhaqaaqa jiirarka, sida lagu tijaabiyay baaritaanka rotarod, taas oo muujinaysa in aysan u horseedin habka dhexe ee neerfayaasha (CNS) waxyeelooyinka la xiriira xakamaynta mootada.
Saamaynta Dhaqdhaqaaqa Locomotor-ka Kediska ah: Qiyaasta 30 mg/kg, lycorine ayaa la arkay si ay u wiiqdo dhaqdhaqaaqa iskiis u shaqeysta ee jiirarka, sida lagu muujiyay hoos u dhaca dhaqanka korinta iyo kororka dhaqdhaqaaq la'aanta.
Dabeecadda Guud iyo Ladnaanta: Qiyaasta 10 mg / kg ee lycorine ma wiiqin dabeecadaha guud iyo fayoobida jiirarka, taas oo soo jeedinaysa in tani ay noqon karto qiyaasta ugu wanaagsan ee qiimeynta waxtarka daaweynta mustaqbalka.
Ma jirto Saamayn Xun oo Muhiim ah oo ku Saabsan Miisaanka Jirka ama Xaaladda Caafimaadka: Maamulka lycorine iyo lycorine hydrochloride ma aysan keenin saameyn muuqata oo dhinaca miisaanka jirka ama guud ahaan xaaladda caafimaad ee moodooyinka jiirka-xambaarsan.
Waxaa muhiim ah in la ogaado in iyada oo lycorine ay muujisay suurtagalnimada baaritaannada saxda ah, qiimeynta sunta muddada-dheer ayaa weli maqan. Cilmi baaris dheeraad ah ayaa loo baahan yahay si si buuxda loo fahmo muuqaalkeeda badbaadada, gaar ahaan isticmaalka muddada dheer iyo goobaha caafimaadka. Dhibaatooyinka soo raaca iyo badbaadada lycorine way kala duwanaan karaan iyadoo ku xiran qiyaasta, habka maamulka, iyo sifooyinka bukaan socodka shakhsi ahaaneed. Had iyo jeer la tasho xirfadle daryeel caafimaad ka hor intaadan tixgelinin isticmaalka kabista ama daaweynta cusub.
