Catharanthus Roseus soo saarta budada
Catharanthus roseus soosaaray budadawaa nooc budo ah oo laga soosaaray geedka Catharanthus roseus, oo sidoo kale loo yaqaan Madagascar periwinkle ama periwinkle rosy. Geedkan waxa uu caan ku yahay dawooyinkeeda waxana uu ka kooban yahay xeryahooda bioactive ee kala duwan, oo ay ku jiraan alkaloids sida vinblastine iyo vincristine, kuwaas oo lagu darsayay sifooyinkooda ka hortagga kansarka.
Budada la soosaaray waxaa sida caadiga ah lagu helaa iyada oo la soo saarayo xeryahooda bioactive ee walxaha dhirta ka dibna lagu farsameeyo qaab budo ah oo loogu talagalay codsiyada kala duwan. Waxa laga yaabaa in loo isticmaalo dawo dhaqameed, dawooyinka, ama goobaha cilmi-baadhista sababtuna tahay sifadeeda daawaynta ee suurtogalka ah.
Catharanthus roseus waxaa loo yaqaanaa inuu yahay warshad dawo ah oo caan ah sababtoo ah waxay ka kooban tahay laba antitumor terpenoid indole alkaloids (TIAs), vinblastine iyo vincristine. Daawo dhaqameedka Shiinaha, waxyaabaha laga soo saaro geedka ayaa loo isticmaalay in lagu daweeyo cudurrada sida duumada, macaanka, iyo Hodgkin's lymphoma. Sanadihii 1950-aadkii, vinca alkaloids ayaa laga soocay Catharanthus roseus iyadoo laga baarayo daawooyinka ka hortagga sonkorowga.
Catharanthus roseus, oo badanaa loo yaqaanindho dhalaalaya, Cape periwinkle, geedka xabaalaha, Madagascar periwinkle, gabadh gabadh ah, periwinkle casaan, orkor u kacay periwinkle, waa nooc ka mid ah dhirta ubaxa ee qoyska Apocynaceae. Waxay asal ahaan ka soo jeedaa Madagascar, laakiin waxay ku koraan meelo kale sida dhirta qurxinta iyo daawooyinka, oo hadda waxay leedahay qaybinta pantropical. Waa isha daawooyinka vincristine iyo vinblastine, oo loo isticmaalo daaweynta kansarka. Horey waxaa loogu dari jiray hiddaha Vinca sidaVinca rosea. Waxay leedahay magacyo luqadeed oo badan oo ay ka mid yihiin arivotaombelona ama rivotambelona, tonga, tongatse ama trongatse, tsimatiririnina, iyo vonenina.
| Walxaha firfircoon ee Shiineeska ah | Magaca Ingiriisiga | CAS Maya. | Miisaanka Molecular | Qaanuunka molecular |
| 长春胺 | Vincamine | 1617-90-9 | 354.44 | C21H26N2O3 |
| 脱水长春碱 | Anhydrovinblastine | 38390-45-3 | 792.96 | C46H56N4O8 |
| 異長春花苷內酰胺 | Strictosamide | 23141-25-5 | 498.53 | C26H30N2O8 |
| 四氢鸭脚木碱 | Tetrahydroalstonine | 6474-90-4 | 352.43 | C21H24N2O3 |
| 酒石酸长春瑞滨 | Vinorelbine Tartrate | 125317-39-7 | 1079.12 | C45H54N4O8.2(C4H6O6);C |
| 长春瑞滨 | Vinorelbine | 71486-22-1 | 778.93 | C45H54N4O8 |
| 长春新碱 | Vincristine | 57-22-7 | 824.96 | C46H56N4O10 |
| 硫酸长春新碱 | Vincristine sulfate | 2068-78-2 | 923.04 | C46H58N4O14S |
| 硫酸长春质碱 | Catharanthine sulfate | 70674-90-7 | 434.51 | C21H26N2O6S |
| 酒石酸长春质碱 | Catharanthine hemitartrate | 4168-17-6 | 486.51 | C21H24N2O2.C4H6O6 |
| 长春花碱 | Vinblastine | 865-21-4 | 810.99 | C46H58N4O9 |
| 长春质碱 | Catharanthine | 2468-21-5 | 336.43 | C21H24N2O2 |
| 文朵灵 | Vindoline | 2182-14-1 | 456.53 | C25H32N2O6 |
| 硫酸长春碱 | Vinblastine sulfate | 143-67-9 | 909.05 | C46H60N4O13S |
| β-谷甾醇 | β-Sitosterol | 83-46-5 | 414.71 | C29H50O |
| 菜油甾醇 | Campesterol | 474-62-4 | 400.68 | C28H48O |
| 齐墩果酸 | Oleanolic acid | 508-02-1 | 456.7 | C30H48O3 |
| QEEXIDDA Alaabada | ||
| Magaca Alaabta: | Vinca rosea asal ahaan | |
| Magaca Botanic: | Catharanthus roseus (L.) | |
| Qayb ka mid ah dhirta | Ubax | |
| Dalka Asal ahaan: | Shiinaha | |
| WAXYAABAHA FALANQAYNTA | QAABKA | Habka tijaabada |
| Muuqashada | budo fiican | Organoleptic |
| Midabka | budo fiican oo bunni ah | Muuqaal |
| Urta & Dhadhanka | Sifada | Organoleptic |
| Aqoonsiga | La mid ah muunadda RS-ga | HPTLC |
| Soo Saarida Saamiga | 4:1-20:1 | |
| Falanqaynta Sieve | 100% ilaa 80 mesh | USP39 <786> |
| Luminta qalajinta | ≤ 5.0% | Eur.Ph.9.0 [2.5.12] |
| Wadarta Dambas | ≤ 5.0% | Eur.Ph.9.0 [2.4.16] |
| hogaanka (Pb) | ≤ 3.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Arsenic (As) | ≤ 1.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Cadmium(Cd) | ≤ 1.0 mg/kg | Eur.Ph.9.0<2.2.58>ICP-MS |
| Meerkuri (Hg) | ≤ 0.1 mg/kg -Reg.EC629/2008 | Eur.Ph.9.0<2.2.58>ICP-MS |
| Bir culus | ≤ 10.0 mg/kg | Eur.Ph.9.0<2.4.8> |
| Haraaga dareeraha | U hoggaansan Eur.ph. 9.0 <5,4> iyo EC Dardaaranka Yurub 2009/32 | Eur.Ph.9.0<2.4.24> |
| Hadhaaga sunta cayayaanka | U hoggaansanaanta Xeerarka (EC) No.396/2005 oo ay ku jiraan lifaaqyo iyo cusbooneysiin xiriir ah Reg.2008/839/CE | Chromatography gaaska |
| Bakteeriyada Aerobic (TAMC) | ≤10000 cfu/g | USP39 <61> |
| Khamiirka/Molds (TAMC) | ≤1000 cfu/g | USP39 <61> |
| Cudurka Escherichia coli: | Maqan 1g | USP39 <62> |
| Salmonella spp: | Maqan 25g | USP39 <62> |
| Staphylococcus aureus: | Maqan 1g | |
| Listeria monocytogenes | Maqan 25g | |
| Aflatoxins B1 | ≤ 5 ppb -Reg.EC 1881/2006 | USP39 <62> |
| Aflatoxins ∑ B1, B2, G1, G2 | ≤ 10 ppb -Reg.EC 1881/2006 | USP39 <62> |
Catharanthus roseus Soosaar budada, ama Vinca rosea soosaaray, oo laga soo qaatay dhirta periwinkle ee Madagascar, waxay leedahay astaamo dhowr ah oo xusid mudan:
Isku-dhafan noole:Budada la soosaaray waxay ka kooban tahay xeryahooda bioactive sida vinblastine iyo vincristine, kuwaas oo loo yaqaan guryaha dawooyinka ee suurtogalka ah, gaar ahaan goobta daaweynta kansarka.
Guryaha Dawooyinka:Budada la soosaaray waxaa lagu qiimeeyaa faa'iidooyinka daawada ee suurtogalka ah, oo ay ku jiraan kansarka ka hortagga, ka hortagga sonkorowga, iyo guryaha ka hortagga hypertensive, iyo kuwo kale.
Isha Dabiiciga ah:Waxay ka timid geedka Catharanthus roseus, oo caan ku ah dhacdooyinka dabiiciga ah iyo isticmaalka daawooyinka dhaqameed.
Codsiyada Daawooyinka:Budada la soosaaray waxay ku habboon tahay in loo isticmaalo hababka dawooyinka iyo cilmi-baarista sababtoo ah dabeecadeeda bioactive iyo codsiyada daweynta ee suurtogalka ah.
Tayada iyo Nadiifinta:Alaabta waxaa loo soo saaray heerar tayo sare leh, iyadoo la hubinayo nadiifnimada, awoodda, iyo joogteynta waxyaabaha ka kooban bioactive.
Xiisaha Cilmi-baarista:Waa mid xiiso u leh cilmi-baarayaasha iyo xirfadlayaasha daryeelka caafimaadka sababtoo ah kartideeda horumarinta alaabada iyo daawaynta cusub ee dawooyinka.
Waa kuwan faa'iidooyinka caafimaad ee Catharanthus roseus Soo saarista Budada ee jumlado gaaban:
1. Guryaha ka hortagga kansarka ee suurtagalka ah ee loo aaneynayo joogitaanka alkaloids vinblastine iyo vincristine.
2. Cilmi-baaristu waxay soo jeedinaysaa saamaynta anti-sonkorowga, laga yaabo inay caawiso maareynta sonkorta dhiigga.
3. Isticmaalka suurtogalka ah ee maareynta hypertension sababtoo ah sifooyinka hypotensive ee la soo sheegay.
4. Waxaa lagu baadhay awooddeeda ka hortagga jeermiska iyo fayraska ee kaalmaynta caafimaadka difaaca.
5. Xiisaha cilmi-baarista ee sifooyinka neuroprotective ee taageerada caafimaadka garashada.
6. Codsiga suurtogalka ah ee qaababka daryeelka maqaarka sababtoo ah sifooyinka antioxidant ee la soo sheegay.
7. Waxaa lagu bartay saameynteeda anti-bararka, taasoo laga yaabo inay saameyn ku yeelato xaalado caafimaad oo kala duwan.
8. Waxa lagu baadhay awoodeeda lagu taageerayo guud ahaan fayoobida iyo firfircoonida.
1. Qaababka ka hortagga kansarka iyo cilmi baarista ay ugu wacan tahay joogitaanka alkaloids vinblastine iyo vincristine.
2. Horumarinta daawooyinka ka hortagga macaanka iyo kaabista.
3. Isticmaalka suurtagalka ah ee maareynta hypertension iyo daawooyinka la xiriira.
4. Cilmi baaris lagu sameeyo wakiilada cusub ee daaweynta xaaladaha caafimaad ee kala duwan.
5. Waxyaalaha ku jira dawada dhaqameedka iyo dawooyinka dhirta.
6. Sahaminta hantideeda loogu talagalay daryeelka maqaarka iyo qaababka qurxinta.
7. Baadhista awoodeeda daaweynta caabuqyada microbial.
8. Horumarinta kaabista cuntada ee taageerada guud ee caafimaadka iyo fayoqabka.
9. Baadhitaan lagu sameeyo faa'iidooyinka caafimaad ee ilaalinta neerfaha iyo garashada.
10. Codsiyada suurtagalka ah ee daawada xoolaha iyo alaabta caafimaadka xoolaha.
Codsiyadani waxay muujinayaan isticmaalka kala duwan ee suurtagalka ah ee Catharanthus roseus Soo saarista Budada ee dhammaan daawooyinka, daryeelka caafimaadka, fayoobida, iyo qaybaha cilmi-baarista.
Catharanthus roseus Soo saarta budada, sida alaabooyin badan oo dabiici ah, ayaa laga yaabaa inay yeelan karaan saameyn liddi ku ah, gaar ahaan marka loo isticmaalo foomamka xoogga leh. Qaar ka mid ah waxyeellooyinka iman kara waxaa ka mid noqon kara:
Qalalaasaha caloosha:Sida lallabbo, matag, ama shuban ku dhaca shakhsiyaadka qaarkood.
Hypotension:Sababo la xiriira sifooyinka hypotensive ee la sheegay, isticmaalka xad-dhaafka ah wuxuu keeni karaa cadaadis dhiig oo hooseeya.
Saamaynta Neerfaha:Qaadashada sare waxay keeni kartaa calaamadaha neerfaha sida dawakhaad ama wareer.
Falcelinta Xasaasiyadda:Shakhsiyaadka qaarkood ayaa laga yaabaa inay dareemaan dareen-celin xasaasiyadeed, gaar ahaan haddii ay ogaadeen xasaasiyadaha dhirta.
Isdhexgalka daroogada:Waxaa laga yaabaa inay la falgasho daawooyinka qaarkood, markaa taxaddar ayaa lagula talinayaa, gaar ahaan shakhsiyaadka daawooyinka kale.
Waa muhiim inaad la tashato xirfadle daryeel caafimaad ka hor inta aanad isticmaalin Catharanthus roseus Soo saarista Budada, gaar ahaan haddii aad leedahay xaalado caafimaad oo hoose ama aad daawo qaadanayso. Tani waxay kaa caawin doontaa in la hubiyo isticmaalkeeda ku habboon oo badbaado leh.
Baakadaha iyo Adeegga
Baakadaha
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